A five-hour layover is not lost time — it is the first night of your destination clock if you handle it right. Treat layover hours by destination clock, not airport location.
Under 90 minutes: move directly to the next gate, hydrate, eat lightly if it fits destination clock.
4–8 hours: find a lounge. Nap only if it is destination night, with two alarms set. Walk and eat at local times during destination day.
Work when you sleep 4–5 continuous hours and arrive into daytime. Fail when shallow sleep dumps you into morning meetings.
For 12+ hour shifts with no premium-cabin sleep, an intentional one-night stopover often beats a single brutal flight.